Detailed Project Report (DPR) on manufacturing medical plastic like catheters, syringe, dextrose saline (i.v.fluid) in plastic bottle, iv set cannula and related materials

 
MANUFACTURING MEDICAL PLASTICS
 LIKE CATHETERS, SYRINGE, DEXTROSE SALINE
(I.V. FLUID) IN PLASTIC BOTTLE,
IV SET CANNULA AND RELATED MATERIALS
(CODE NO. 1995)


There is a huge demand of Medical Plastics in India and abroad, Many items can be produces in this category.

CATHETERS

A catheter is a flexible tube made of latex, silicone, or Teflon that can be inserted into the body creating a channel for the passage of fluid or the entry of a medical device. For many years, the epidermal catheters used were plain tubes made of available industrial compounds, and design was largely based on current need. In the 1950s and early 1960s, a very common practice was to cut a suitable length of industrial polyvinyl chloride (PVC) or nylon tubing and have it sterilized with the other surgical equipment. Nowadays, there are many specialized catheter designs. For example, specific catheter designs allow catheters to be used in pulmonary, cardiac (vascular), neonatal, central nervous system, and epidural tissues. Catheters are designed to perform tissue ablation (tissue removal) and even serve as conduits for thermal, optics, and various medical devices.

The three major types of catheters are coronary, renal, and infusion. Coronary catheters are used for angiography (x-ray of blood vessels after injection of radiopaque substance), angioplasty (altering the structure of a vessel), and ultrasound procedures in the heart or in peripheral veins and arteries. The best-known renal catheters are Foley catheters, which have been commercially available since the 1930s. These catheters are equipped with an inflatable balloon at the tip and are used for urine incontinence, dying patients, and bladder drainage following surgery or an incapacitating injury or illness. The Foley catheter is relatively easy to use and used throughout the world in hospitals, nursing homes, and home-care settings.


Catheters are flexible, hollow tubes which allow blood to flow in and out of your body. They are most commonly used as a temporary access for up to three weeks. This is often done when a patient needs dialysis immediately and is waiting for a fistula or graft to mature. They are also used when a permanent access fails and a patient is too unstable to delay treatment. Several different types of catheters exist. Or we can say that a catheter is a tube put into the body, usually by a medical person, to let fluids drain out. It is often used when the person cannot urinate, as during and right after surgery.

It can also be used to drain pus or blood out of a wound. It is very bad to reuse one as it can have germs on it from the first use. It must be inserted in a very sanitary method so as not to introduce germs into the person. Many folks that have illnesses that makes it difficult to urinate must have them in all the time and sometimes get urinary tract infections if they are not changed often and in a safe manner.

Catheter refers to a central venous catheter (CVC) or a central line.

Hub refers to the end of the CVC that connects to the blood lines or cap.

Cap refers to a device that screws on to and occludes the hub.

Limb refers to the catheter portion that extends from the patient’s body to the hub.

Blood lines refer to the arterial and venous ends of the extracorporeal circuit that connect the patient’s catheter to the dialyzer.

History:

The earliest precursor to the present day Foley catheter is documented in 3000 B.C. It is believed that Egyptians used metal pipes to perform bladder catheterizations. As early as 400 B.C. hollow reeds and pipes were used in cadavers to study the form and function of cardiac valves.

In 1844, Claude Bernard inserted a mercury thermometer into the carotid artery of a horse and advanced it through the aortic valve into the left ventricle to measure blood temperature. It is because of his work that the use of catheters became the method of standard for physiologists in the study of cardiovascular blood flow. Adolph Fick took another major step in the development of cardiac catheterization in 1870. His famous note on the calculation of blood flow is the basis for today's cardiac procedures.

Among the earliest published descriptions of human catheterization were done by Frizt Bleichroeder, E. Unger, and W. Loeb in 1912. They were among the first to insert catheters into the blood vessels without x-ray visualization. Interest in catheterization was also stimulated with the advent of chemotherapy. Early chemotherapy required the injection of drugs directly into the central circulation. Bleichroeder inserted catheters into dog arteries and assessed the effects after leaving them in place for several hours. He reported no complications or clots.

The Foley catheter came into existence in the 1930s. Frederick E. B. Foley began to experiment with different catheters of the time. He realized that urinary catheters would easily slip out of the bladder because there was no way to hold them in place. Foley experimented with different methods.


COST ESTIMATION

Plant capacity                                     MANUFACTURING MEDICAL PLASTIC LIKE              
Land & Building (15000 Sq.Yd)           Rs. 22.90 Cr
lant & Machinery                                 Rs. 37.32 Cr
W.C. for 2 Months                               Rs. 6.81  Cr
Total Capital Investment                      Rs. 70.28 Cr
Rate of Return                                    19%
Break Even Point                                60%


INTRODUCTION    
KEY TERMS IN IV FLUIDS    
DEXTROSE    
CATHETES LENGTH, SIZES & TYPES    
TYPES    
DIAMETERS:    
TYPES AND BRIEF DESCRIPTION OF CATHETERS    
MATERIALS USED IN CATHETER    
ADVANTAGES & DISADVANTAGE OF CATHETER    
CENTRAL VENOUS CATHETER    
PROPERTIES OF DEXTROSE    
PROPERTIES    
RAW MATERIALS REQUIREMENT FOR IV FLUID    
BLOW FILL SEAL (BFS) TECHNOLOGY    
MEDICAL BLOW-FILL-SEAL    
SOURCE OF MACHINES TECHNOLOGY    
USES AND APPLICATION    
PROPERTIES AND CHARACTERISTICS    
DISPOSABLE SYRINGE TECHNCAL ANALYSIS    
MARKET SURVEY    
SUMMARY FIGURE    
GLOBAL CATHETER MARKET, BY REGION, 2011 AND 2016 (%)    
ECONOMIC PROFILE    
WORLD MARKET CONSUMPTION    
PRODUCTION OF SYRINGES AND NEEDLES    
MANUFACTURERS AND SUPPLIERS OF DISPOSABLE SYRINGES    
POTENTIAL CONSUMERS    
IMPORT OF SURGICAL GLOVES    
INSTALLED CAPACITY, UTILIZATION & PRODUCTION OF SURGICAL GLOVES    
APPARENT CONSUMPTION OF SURGICAL GLOVES    
ESTIMATED DEMAND    
DEMAND SUPPLY GAP    
PRESENT MANUFACTURERS/SUPPLIERS OF SURGICAL GLOVES    
OVERVIEW OF INDIAN DRUGS AND PHARMACEUTICALS INDUSTRY    
GLOBAL MARKET POSITION OF MEDICAL DISPOSABLES    
PRESENT MANUFACTURERS OF I.V. SET    
B. I. S. SPECIFICATION    
MANUFACTURING PROCESS OF CATHETER    
PROCESS FLOW DIAGRAM    
CATHETER DESIGN AND MATERIALS    
HUB OPTIMIZATION AND INTEGRATIO OF HIGH-PERFORMANCE CATHETERS    
MANUFACTURING PROCESS OF DISPOSABLE PLASTIC SYRINGE    
PROCESS FLOW DIAGRAM OF DISPOSABLE PLASTIC SYRINGE    
DETAILS OF PLASTIC PART PROCESSING AND STERILIZATION    
FACTORS INFLUENCING ETHYLENE OXIDE STERILIZATION    
MANUFACTURING PROCESS OF I.V. SET CANNULA    
PROCESS FLOW DIAGRAM OF I.V. SET    
PROCESS IN DETAILS    
EXTRUSION PROCESS OF PVC MEDICAL TUBING    
TECHNOLOGY AND PRODUCTION PROCESS FOR SURGICAL GLOVES    
MANUFACTURING FLOW CHART FOR
PROCESSING METHOD OF SURGICAL GLOVES    
MANUFACTURING PROCESS OF SURGICAL GLOVES    
FORMULATION OF SURGICAL GLOVES    
PROCESS FLOW FOR MANUFACTURE OF NON-STERILE SURGICAL GLOVES    
MANUFACTURING PROCESS OF FFS TECHNOLOGY
MANUFACTURING PROCESS UNDER B.F.S./F.F.S.    
SCHEMATIC DIAGRAM OF BFS PRODUCTION PROCESS    
FLOW DIAGRAM OF MANUFACTURING OF I.V. FLUIDS    
SPECIFICATION OF EFFLUENT DISCHARGE OF PHARMACEUTICAL INDUSTRY    
LIST OF MACHINERY IV BAG PRODUCTION FORM FILL AND SEAL MACHINE    
CIP SYSTEM    
DETAILS OF EQUIPMENTS & MACHINERY FOR CATHETER    
SUPPLIERS OF PLANT & MACHINERY    
SUPPLIERS OF RAW MATERIALS    

APPENDIX – A :

 1.      COST OF PLANT ECONOMICS      
 2.      LAND & BUILDING                                      
 3.      PLANT AND MACHINERY                                  
 4.      FIXED CAPITAL INVESTMENT                             
 5.      RAW MATERIAL                                         
 6.      SALARY AND WAGES                                     
 7.      UTILITIES AND OVERHEADS                              
 8.      TOTAL WORKING CAPITAL                                
 9.      COST OF PRODUCTION                                   
10.      PROFITABILITY ANALYSIS                               
11.      BREAK EVEN POINT                                     
12.      RESOURCES OF FINANCE                           
13.      INTEREST CHART                                       
14.      DEPRECIATION CHART                                   
15.      CASH FLOW STATEMENT                                   
16.      PROJECTED BALANCE SHEET