MANUFACTURING SANITIZER, HAND WASH,
POVIDONE IODINE, GLUCOSE BOTTLE
[CODE NO.3893]
Intravenous fluids, in general are used as I.V drips for patients in nursing homes and hospitals suffering from acute dehydration or considerable debilitating conditions. These I.V fluids replenish the body fluids. Though a number of I.V fluids are there, generally three types of I.V fluids are used in hospitals as I.V drips. They are as follows:-
1. Dextrose injection fluid
2. Dextrose and sodium chloride injection fluid
Types of IV Fluid
Crystalloid: Balanced salt/electrolyte solution; for msa true solution and is capable of passing through semi permeable membranes. May be isotonic, hypertonic or hypotonic. Normal Saline (0.9% NaCl), Lactated Ringer’s, Hypertonic saline (3, 5, & 7.5%), Ringer’s solution. However, hypertonic solutions are considered plasma expanders as they act to increase the circulatory volume via movement of intracellular and interstitial water into the intravascular space.
Colloid: High-molecular-weight solutions, draw fluid into intravascular compartment via on cotic pressure (pressure exerted by plasma proteins not capable of passing through membranes on capillary walls).Plasma expanders, as they are composed of macromolecules, and are retained in the intravascular space.
Free H2O solutions: provide water that is not bound by macromolecules or organelles, free to passthrough.D5W (5% dextrose in water), D10W, D20W, D50W, and Dextrose/crystalloid mixes. Blood products: whole blood, packed RBCs, FFP, Cryoprecipitate, platelets, albumin essentially all colloids.
COST ESTIMATION
Plant Capacity 100 Ltr/Day
Land & Building (30000 sq.mt.) Rs. 1.84 Cr
Plant & Machinery Rs. 52.00 Lacs
Working Capital for 2 Months Rs. 75.76 Lacs
Total Capital Investment Rs. 3.35 Cr
Rate of Return 23%
Break Even Point 69%
INTRODUCTION
TYPES OF IV FLUID
HOW INTRAVENOUS FLUIDS ARE CREATED
PHENYL IS AVAILABLE IN TWO FORMS
IV FLUID/ELECTROLYTE THERAPY
KEY TERMS
DEXTROSE
DEXTROSE SALINE INJECTION
PROPERTIES OF GLOCOSE
TABLE I. PHYSICAL PROPERTIES OF D-GLUCOSE
TABLE 2. SOLUBILITY OF DEXTROSE IN WATER
PROPERTIES OF GOOD PHENYL
PROPERTIES OF HAND WASH
REQUIREMENTS FOR LIQUID TOILET SOAP
USES AND APPLICATION OF PHENYL
CLASS, GRADE AND TYPE DISINFECTANT FLUID (TYPE)
REQUIREMENT OF DISINFECTANT FLUID
COMPOSITION AND DESCRIPTION
BLACK FLUIDS
WHITE FLUIDS
STABILITY AFTER DILUTION
GERMICIDAL VALUE
MERCURY COMPOUNDS
B.I.S SPECIFICATIONS
INDIAN STANDARDS:-
USES AND APPLICATION OF HAND WASH
REQUIREMENTS OF RAW MATERIALS FOR IV FLUID
TABLE I: REQUIREMENT FOR DEXTROSE MONOHYDRATE
RAW MATERIAL FOR HAND WASH
MARKET POSITION OF PHENYL
PRESENT MANUFACTURERS OF PHENYL
RAW MATERIALS FOR PHENYL PRODUCTION
GENERAL FORMULATION OF PHENYL (ORDINARY TYPE)
TYPICAL FORMULATION OF PHENYL
FORMULATION AND PROCESS OF BLACK PHENYL
FORMULATION
PROCESS OF PINE OIL DISINFECTANT & FORMULATION (COLD PROCESS)
FORMULATION
MANUFACTURING PROCESS & FORMULATIONS
CHEAP QUALITY PHENYL
GOOD MEDIUM QUALITY PHENYL:-
BEST TYPES OF PHENYLS
FORMULATION - I
FORMULATION - II:
GOOD HOSPITAL QUALITY PHENYL
FORMULATIONS FOR PERFUMED PHENYL (THICK)
WATER IS ADJUSTED FOR DESIRED CONSISTENCY
PERFUMED PHENYL (THICK)
FORMULATION:-
WATER TO BE ADJUSTED FOR DESIRED CONSISTENCY.
HIGH BOILING TAR ACID BLACK FLUIDS (PHENYL)
FORMULATION (WHITE PHENYL)
FORMULATION - 1
FORMULATION - 2
FORMULATION - 3
BROWN PHENYL
PHENYL IS AVAILABLE IN TWO FORMS.
WHITE PHENYL (SOLID TYPE)
PROCESS FLOW DIAGRAM
PACKAGING AND MARKING OF DISINFECTANT FLUID
MARKING
BIS CERTIFICATION MARKING
TESTING METHOD OF DISINFECTANT FLUID
METHOD FOR DETERMINATION OF STABILITY AFTER DILUTION
A-1 PREPARATION OF SAMPLE
A-2 DILUTION WATER
DETERMINATION OF RIDEAL WALKER (RW) COEFFICIENT
B-0 GENERAL
B-1 APPARATUS
B-2 REAGENTS
B-3 PREPARATION OF CULTURES
B-4 DETERMINATION OF PHENOL COEFFICIENT
B-5 CALCULATION
TABLE 1 TYPICAL SET OF RESULTS – RIDEAL WALKER COEFFICIENT
TABLE 2 RIDEAL WALKER COEFFICIENTS FOR DIFFERENT DILUTIONS (CLAUSES B-4.2 AND B-5.4)
DETERMINATION OF STAPHYLOCOCCAL COFFICIENT
C-I APPARATUS
C-2 REAGENTS
C-3 PREPARATION OF CULTURE
C-4 DETERMINATION OF PHENOL COEFFICIENT
C-5 CALCULATION
DETERMINATION OF MERCURY COMPOUNDS
D. PROCEDURE
SAMPLING OF DISINFECTANT FLUIDS, PHENOLIC TYPE
E. GENERAL REQUIREMENTS
TABLE 4 SCALE OF SAMPLING
MARKET POSITION OF HAND WASH
HAND WASH MARKET IN INDIA:
EVOLUTION OF HAND WASH MARKET IN INDIA
MAIN PLAYERS IN THE HAND WASH MARKET:
TREND IN HAND WASH MARKET IN INDIA
MAJOR MARKETING CAMPAIGNS BY MAJOR BRANDS:
SOME STARK FACTS ABOUT DIARRHEA
BANEGA SWACH INDIA CAMPAIGN:
GROWTH DRIVERS OF BUSINESS OF HANDWASH:
EXPORT DATA OF LIQUID HAND WASH
FORMULATION OF HAND WASH
MANUFACTURING PROCESS OF HAND WASH (LIQUID)
PROCESS IN DETAILS
PREPARATORY STEPS
BATCHING
FILLING/PACKAGING
FORMULATIONS OF LIQUID HAND SOAP
FORMULATION-1
FORMULATION-2
FORMULATION-3
FORMULATION-4
FORMULATION OF LIQUID HAND WASH SOAP
FORMULATION OF LIQUID HAND WASH 110
PROCESS FLOW DIAGRAM
EXPORT OPPORTUNITY OF INTRAVENOUS SOLUTION
LOCAL MANUFACTURING ACTIVITIES
WORLD MARKET TRENDS IMPORTS & EXPORTS
MAJOR INTERNATIONAL IMPORTING COUNTRIES
MAJOR IMPORTING COUNTRIES - MENA REGIONAL & GCC
COMPETITION - MAJOR EXPORTING COUNTRIES
ESTIMATE OF IMPORTER’S LANDED COSTS
ECONOMIC PROFILE FOR IV FLUID
WORLD MARKET CONSUMPTION
SOURCE OF MACHINES TECHNOLOGY FOR IV FLUID
GLOBAL MARKET OVERVIEW OF IV FLUID
GEOGRAPHICAL SEGMENTATION OF THE INTRAVENOUS
SOLUTIONS MARKET
COMPETITIVE LANDSCAPE AND KEY VENDORS
KEY VENDORS IN THIS MARKET ARE -
GROWTH DRIVERS, CHALLENGES, AND UPCOMING TRENDS:
HOME TREATMENT
USES AND APPLICATION GLUCOSE (IV FLUID)
SOME GENERAL INTRAVENOUS FLUIDS
SPECIFICATION OF INDIAN PHARMACOPEIA ON I.V FLUIDS
DEXTRAN 40 INJECTION
DEXTRAN 110 INJECTIONS
B.I.S. SPECIFICATIONS FOR PLASTIC I.V. BOTTLES 139
FORMULATION AND PROCESS OF HAND SANITIZER & POVIDONE IODINE
FORMULATION OF ALCOHOL BASED HERBAL HAND SANITIZER
WHO RECOMMENDED HAND AUTO FORMULATION 50 LTR/LOT
ALCOHOL BASED HAND RUB
FORMULATION-1
FORMULA:II
FORMULATION-1 ETHANOL ANTISEPTIC 80%
FORMULATION OF HAND SANITIZER (ISOPROPANOL BASED)
75% TYPICAL SOLUTION
FORMULATIONOF HAND WASH
COMPOSITION OF POVIDONE IODINE SOLUTION
PREPARATION OF POVIDONE IODINE SOLUTION
SODIUM CHLORIDE AND DEXTROSE INJECTION
BASIC RAW MATERIALS
REQUIREMENTS OF RAW MATERIALS AND SPECIFICATIONS FOR IV FLUID
WATER FOR INJECTION
HDPE PHARMA GRADE LAMINATE/ PLASTIC ROLL
LABELING
IDENTIFICATION
HEAVY METALS
COMPOSITION OF IV FLUID
COMPOSITION OF COMMON IV FLUID (MEQ/L)
COMPOSITION OF IV FLUIDS
COMPOSITION OF COMMERCIAL I.V. FLUID AVAILABLE
BASIS OF BFS TECHNOLOGY 159
BLOW FILL SEAL (BFS) AND FORM FILL SEAL (FFS) TECHNOLOGY
CONCEPT OF BFS
MANUFACTURING PROCESS OF I.V. FLUID (FFS TECHNOLOGY)
A TYPICAL FFS PROCESS WORKS AS FOLLOWS:
PROCESS FLOW DIAGRAM
PROCESS IN DETAILS
1. DISTILLED WATER PREPARATION:-
2. SOLUTION PREPARATION:-
3. INJECTION BLOW MOULDING
4. MOULDING PROCESS
5. FILLING PROCESS
6. SEALING PROCESS
7. MOULD OPENING PROCESS
FILTRATION AND FILLING:-
STERILIZATION:-
QUALITY CONTROL:-
THE WHOLE PROCESS CONSISTS OF THE FOLLOWING STEPS:-
FLOW DIAGRAM OF MANUFACTURING OF I.V. FLUIDS
SWOT ANALYSIS
FORM FILL SEAL TECHNOLOGY
1. FORM-FILL-SEAL TECHNOLOGY:-
LIST OF MACHINERY IV BAG PRODUCTION FORM FILL AND SEAL MACHINE
1. WATER PURIFYING
2. DISTILLATION
3. SOLUTION FILLING
4. STERILIZATION
5. PACKING
A TYPICAL FFS PROCESS WORKS AS FOLLOWS.
SUPPLIERS OF RAW MATERIALS FOR IV FLUID
POTASSIUM PERMANGANATE
SODIUM CHLORIDE (I.P. GRADE)
DEXTROSE
MACHINERY SUPPLIERS FOR HAND SANITIZER, PHENY
AND POVIDONE SOLUTION
SUPPLIERS OF PLANT AND MACHINERY FOR GLUCOSE BOTTLE
STERILIZING EQUIPMENTS
PM METER
LABELING MACHINES
TANKS
BOILER
FILTER PRESS
LABORATORY EQUIPMENTS
MIXER
EMPTY IV BAG MANUFACTURER AND SUPPLIER IN INDIA
SUPPLIERS OF COMPLETE PLANT AND MACHINERY FOR IV FLUID
CONSULTANT OF TURNKEY PROJECT SUPPLIER OF THE PLANT
AND MACHINERY FOR IV FLUID
CLEAN ROOM SUPPLIERS
MACHINERY CATALOG FOR IV FLUID
APPENDIX – A:
01. PLANT ECONOMICS
02. LAND & BUILDING
03. PLANT AND MACHINERY
04. OTHER FIXED ASSESTS
05. FIXED CAPITAL
06. RAW MATERIAL
07. SALARY AND WAGES
08. UTILITIES AND OVERHEADS
09. TOTAL WORKING CAPITAL
10. TOTAL CAPITAL INVESTMENT
11. COST OF PRODUCTION
12. TURN OVER/ANNUM
13. BREAK EVEN POINT
14. RESOURCES FOR FINANCE
15. INSTALMENT PAYABLE IN 5 YEARS
16. DEPRECIATION CHART FOR 5 YEARS
17. PROFIT ANALYSIS FOR 5 YEARS
18. PROJECTED BALANCE SHEET FOR (5 YEARS)
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