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    Detailed Project Report on iv solution bottle filling plant

    Detailed Project Report on iv solution bottle filling plant
    Detailed Project Report on iv solution bottle filling plant
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      I V SOLUTION BOTTLE FILLING PLANT
      [CODE NO.3410]  


      Intra venous fluids, in general are used as I.V drips for patients in nursing homes and hospitals suffering from acute dehydration or considerable debilitating conditions.  These I.V fluids replanish the body fluids. Though a number of I.V fluids are there, generally three types of I.V fluids are used in hospitals as I.V drips. They are as follows:-

        1. Dextrose injection fluid

        2. Dextrose  and sodium chloride injection fluid

      Types of IV Fluid

      Crystalloid: Balanced salt/electrolyte solution; for msa true solution and is capable of passing through semi permeable membranes. May be isotonic, hypertonic or hypotonic. Normal Saline (0.9% NaCl), Lactated Ringer’s, Hypertonic saline (3, 5, & 7.5%), Ringer’s solution. However, hypertonic solutions are considered plasma expanders as they act to increase the circulatory volume via movement of intracellular and interstitial water into the intravascular space.


      Colloid: High-molecular-weight solutions, draw fluid into intravascular compartment via on cotic pressure (pressure exerted by plasma proteins not capable of passing through membranes on capillary walls).Plasma expanders, as they are composed of macromolecules, and are retained in the intravascular space.

      Free H2O solutions: provide water that is not bound by macromolecules or organelles, free to passthrough.D5W (5% dextrose in water), D10W, D20W, D50W, and Dextrose/crystalloid mixes. Blood products: whole blood, packed RBCs, FFP, Cryoprecipitate, platelets, albumin. Essentially all colloids.

      COST ESTIMATION

      Plant  Capacity                                              :     60000.00 BOTTLES/day  
      land & Building (6000 Sq.Mtr)                     :    Rs.  3.69  Cr
      Plant & Machinery                                          :    Rs.  12.00 Cr
      Working Capital for 2 Months                      :    Rs.  2.06  Cr
      Total Capital Investment                                :   Rs.  18.12 Cr
      Rate of Return                                                 :    22%
      Break Even Point                                            :    61%

      INTRODUCTION    
      INTRAVENOUS FLUIDS    
      IV FLUID/ELECTROLYTE THERAPY    
      KEY TERMS    
      DEXTROSE    
      DEXTROSE SALINE INJECTION    
      PROPERTIES    
      REQUIREMENTS OF RAW MATERIALS    
      EXPORT OPPORTUNITY OF INTRAVENOUS SOLUTION    
      INTERNATIONAL MARKET OVERVIEW    
      ECONOMIC PROFILE    
      WORLD MARKET CONSUMPTION    
      SOURCE OF MACHINES TECHNOLOGY    
      OVERVIEW OF THE GLOBAL INTRAVENOUS SOLUTIONS MARKET    
      IV FLUID PRODUCTION CAPACITY AND MARKET DEMAND IN AFGHANISTAN    
      USES AND APPLICATION    
      SOME GENERAL INTRAVENOUS FLUIDS    
      MARKET SURVEY    
      MARKET STRACTURE    
      INDIAN BULK DRUG MARKET SHARE    
      ADDITIONAL MARKET POSITION    
      INDIAN PATENTS LAW, TRADE LAW & TAXATION    
      'TAX'ING INDIAN PHARMA    
      PRESENT MANUFACTURES OF I.V FLUIDS    
      SPECIFICATION OF INDIAN PHARMACOPEIA ON I.V FLUIDS DEXTRAN     
      40 INJECTION    
      DEXTRAN 110 INJECTIONS    
      B.I.S. SPECIFICATIONS FOR PLASTIC I.V. BOTTLES    
      SODIUM CHLORIDE AND DEXTROSE INJECTION    
      WATER THE EXCELLENT SOLVENT USED IN PHARMACY    
      BASIC RAW MATERIALS    
      REQUIREMENTS OF RAW MATERIALS AND SPECIFICATIONS    
      COMPOSITION OF IV FLUID    
      COMPOSITION OF COMMON IV FLUID (MEQ/L)    
      COMPOSITION OF IV FLUIDS    
      COMPOSITION OF COMMERCIAL I.V. FLUID AVAILABLE    
      MANUFACTURING PROCESS OF I.V. FLUID (FFS TECHNOLOGY)    
      PROCESS FLOW DIAGRAM    
      PROCESS IN DETAILS    
      FLOW DIAGRAM OF MANUFACTURING OF I.V. FLUIDS    
      PLANT LAYOUT    
      SWOT ANALYSIS    
      SCHEMATIC DIAGRAM OF FFS PLANT LAYOUT    
      FORM FILL SEAL TECHNOLOGY    
      CALCULATING INTRAVENOUS FLOW RATES    
      GENERAL PLANT LAYOUT    
      MANPOWER    
      LIST OF MACHINERY IV BAG PRODUCTION FORM FILL AND SEAL MACHINE    
      CIP SYSTEM    
      GUIDE TO GOOD MANUFACTURING PRACTICE (GMP) FOR MEDICINAL PRODUCT PRINCIPLE    
      CLEAN ROOM AND CLEAN AIR DEVICE CLASSIFICATION    
      CLEAN ROOM AND CLEAN AIR DEVICE MONITORING    
      ISOLATOR TECHNOLOGY    
      TERMINALLY STERILISED PRODUCTS    
      ASEPTIC PREPARATION    
      PERSONNEL    
      PREMISES    
      EQUIPMENT    
      SANITATION    
      PROCESSING    
      STERILISATION    
      STERILISATION BY HEAT    
      MOIST HEAT    
      STERILISATION BY RADIATION    
      STERILISATION WITH ETHYLENE OXIDE    
      FILTRATION OF MEDICINAL PRODUCTS WHICH CANNOT
      BE STERILISED IN THEIR FINAL CONTAINER    
      FINISHING OF STERILE PRODUCTS    
      SUPPLIERS OF RAW MATERIALS    
      EMPTY IV BAG MANUFACTURER AND SUPPLIER IN INDIA    
      COMPLETE PLANT SUPPLIERS    
      SUPPLIERS OF PLANT AND MACHINEY    
      CONSULTANT OF TURNKEY PROJECT SUPPLIER
      OF THE PLANT AND MACHINERY    
      CLEAN ROOM SUPPLIERS    

      APPENDIX – A:

       1.      COST OF PLANT ECONOMICS      
       2.      LAND & BUILDING                                      
       3.      PLANT AND MACHINERY                                  
       4.      FIXED CAPITAL INVESTMENT                             
       5.      RAW MATERIAL                                         
       6.      SALARY AND WAGES                                     
       7.      UTILITIES AND OVERHEADS                              
       8.      TOTAL WORKING CAPITAL                                
       9.      COST OF PRODUCTION                                   
      10.      PROFITABILITY ANALYSIS                               
      11.      BREAK EVEN POINT                                     
      12.      RESOURCES OF FINANCE                           
      13.      INTEREST CHART                                       
      14.      DEPRECIATION CHART                                   
      15.      CASH FLOW STATEMENT                                   
      16.      PROJECTED BALANCE SHEET      
       

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